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Pan American Expedition | part 3 Cusco – Santiago

6 August, 2025

Pan American Expedition | part 3 Cusco – Santiago

Route
Expedition information
  • August 6 – September 6, 2027
  • 32 days
  • 4.750 km
  • 4

Pan American Expedition | part 3

Cusco - Santiago

On August 6th, we begin our journey in the vibrant city of Cusco, Peru, and make our way to the bustling capital of Chile, Santiago. This expedition combines a thrilling mix of terrains: high-altitude plateaus, salt flats and other natural wonders. Along the route, we traverse the Andes Mountains, immersing ourselves in the awe-inspiring landscapes of Peru, Bolivia, Chile and Argentina.

Highlights

Some highlights of the expedition:

  • Lake Titicaca, South America’s largest freshwater lake, nestled high in the Andes. Explore the shores of this legendary lake, the highest navigable in the world, and experience the unique local culture.
  • La Paz, Bolivia, a city perched dramatically within a canyon carved by the Choqueyapu River. Think vibrant culture, colorful streets, and beautiful surrounding landscapes.
  • For the thrill-seekers: conquer El Camino de la Muerte, the legendary “Death Road,” where adrenaline and awe collide on this narrow, winding path from La Paz to Coroico.
  • Bolivia’s salt flats. Glistening salt, contrasting with vivid red mountains and deep blue skies. Perfect for surreal photos.
  • Potosí silver mine: gain a unique insight into the daily life of a miner as we explore one of the world’s most famous historic silver mines.
  • As we enter Argentina, the landscapes continue to surprise. Witness a desert of fossilized dunes millions of years old, and one of the world’s largest fields of pumice stone formations. Experience the dramatic rock formations of Cañon de Talampaya in Talampaya National Park, and hike through El Leoncito National Park.
  • Mendoza, Argentina, awaits with its world-renowned wine (mainly Malbec). And this is only a taste of what Argentina has to offer. You’ll see different sides of the country in the next leg of the expedition.
  • Atacama Desert, Chile: stretch along nearly 1,000 km of the driest non-polar desert on Earth. Witness dramatic salt flats, and, at night, a star-studded sky unlike any other.
  • Along the way, encounters with alpacas and other iconic Andean wildlife add a charming touch to your adventure.

Safety is our priority, so we’ll assess the road’s conditions and suitability for your vehicle before embarking on this adventure.

s
31 nights
w
Guided tour
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Level: 4

Video

Sneak Peek

This video isn’t from this exact expedition, but from one of our earlier South American car journeys. It gives a taste of the landscapes, activities, and experiences you can expect.

On many of our truck expeditions, a videographer travels along, which is why we have more truck videos available. This expedition follows a similar route to this Pan American Expedition part 3, just with a different type of vehicle.

Rent a ready-to-go expedition vehicle

Don’t have a suitable 4×4 for this leg of the adventure?

You can simply rent one from us. Choose between a Toyota Double Cab pickup or a Land Cruiser 78, available for two or four travellers. All vehicles are recent models (max. 5 years old) and carefully outfitted by Overland Travel for remote, long-distance travel.

Your rental car comes loaded with all the essentials: a fridge, air compressor, rooftop tent setup (one or two depending on the model), full sleeping gear, Starlink satellite communication (subscription included), VHF radio, Garmin navigation, long-range fuel tank, necessary tools, recovery equipment and spare parts. Everything is already taken care of. Just arrive, hop in, and hit the road.

Thinking long-term? You also have the possibility to purchase the car afterwards at an attractive rate.

What do we offer?

Fully organized and hassle-free: your focus is simply to drive, explore and enjoy the adventure.

The expedition includes a detailed adventure road book, off-road guidance, and full technical support along the way.

A balanced mix of cultural experiences and natural beauty.

Overnight stays at carefully chosen locations: hotels, campsites, or bivouacs.

Plenty of fun, memorable moments, and stories to share.

Optional: vehicle shipping and support.

Follow Up Expedition(s)

Are you still yearning for more of South America’s wonders? We also have a follow-up trip planned for this expedition (not included in the price of part 1 or 2 or 3 of the expedition). Picture this: embarking on the last leg of our expedition from Santiago to Ushuaia, where the breathtaking landscapes continue to amaze. We can take care of the storage of your vehicle (price on request) in a secure area, so you can seamlessly continue your journey. No need to worry about shipping your truck again! Mark your calendars for November when the follow-up expedition begins, right from where we left off. This means you can hop back on board and dive into the next chapter of the adventure without any hassle. You have the option to book the expeditions separately, but we recommend experiencing them in combination to truly immerse yourself in the South American magic.

Want to join this expedition?

Start with this form.

Would you like to receive the digital brochure with all the details about this expedition? Do you have questions, or are you ready to register? Just fill in the form, and we’ll get in touch with you.



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